We don’t know how the random combining of DNA segments to create antigen binding sites, which in a real sense are what having an immune sensitivity to Panda Wearing Mask Quarantine Christmas 2020 shirt, manage to create combinations to actual things that exist on earth. The random process of creating these generates trillions of them in a shotgun approach. That includes antigen binding sites that bind to all different parts of the common cold rhinovirus as well as making antigen binding sites to molecules that don’t exist on earth. The search space is so huge that really, humans would be lucky to have one antigen binding site that would correspond to anything on earth once in their life, much less when that antigen happens to be in their system.
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Another great mystery of the immune system is clonal selection. In that random process the body makes antigen binding sites that are built to bind to the Panda Wearing Mask Quarantine Christmas 2020 shirt. If left alone those sites turn into auto immune disease, causing the immune system to attack the tissues of the body. Somehow in the process of clonal selection the body is able to destroy the new cells carrying antigen binding sites that could harm it. There is no logical explanation for how the body can differentiate between a legitimate antigen binding site and one that would result in auto immunity. Whomever figures that out gets the next Nobel in Immunology.
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We figured out a long time ago that if we put into the body something shaped like a deadly antigen (a dead virus, parts of a Panda Wearing Mask Quarantine Christmas 2020 shirt, parts of viral RNA, etc) and a person happens to have an antigen binding site active at that time that binds something we inject… you can end up with long term immune memory to that specific antigen shape. That’s all we know. The immune system is probably the most complicated system in the body, because it somehow has information about the outside world and is constantly maintaining the “self” vs. “not self” paradigm inside the body.